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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36919	1α-Hydroxy-3-epi-vitamin D3 1α-Hydroxy-3-epi-vitamin D3
	1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion[1].
T35500	3-epi-25-hydroxy Vitamin D3 3-epi-25-hydroxy Vitamin D3
	3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)
T72726	3-epi-Vitamin D3 Epicholecalciferol
	3-epi-Vitamin D3 (Epicholecalciferol) 是维生素 D3 类似物，是一种Hedgehogpathway 抑制剂，在U87MG 细胞中测定的IC50为 39.2 μM。
T19123	3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether	Others	Others
	3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.
T39184	Tachysterol 3
	Tachysterol 3 is a side product in vitamin D photosynthesis.
T40601	Lumisterol 3 (>90%) CholecalciferolEPImpurityA,Lumisterol 3 (>90%),9β,10α-Cholesta-5,7-dien-3β-ol
	Lumisterol 3 (>90%; 9β,10α-Cholesta-5,7-dien-3β-ol) is a predominant secosteroid metabolite found in humans, belonging to the class of vitamin D3 photoisomer derivatives. It is utilized in the synthesis of vitamin D.
T35524	(1S)-Calcitriol
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr...
T36137	Biotin (S)-sulfoxide
	Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of...

化合物

1α-Hydroxy-3-epi-vitamin D3

Cat.No: T36919

Synonym: 1α-Hydroxy-3-epi-vitamin D3

Target:

3-epi-25-hydroxy Vitamin D3

Cat.No: T35500

Synonym: 3-epi-25-hydroxy Vitamin D3

Target:

3-epi-Vitamin D3

Cat.No: T72726

Synonym: Epicholecalciferol

Target:

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

Cat.No: T19123

Synonym: 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether

Synonym: CholecalciferolEPImpurityA,Lumisterol 3 (>90%),9β,10α-Cholesta-5,7-dien-3β-ol

Cat. No.	Product Name	Target	Signaling Pathways
T1135	Vitamin D3 维生素D3,Cholecalciferol,Colecalciferol	Endogenous Metabolite	Metabolism
	Vitamin D3 (Cholecalciferol) 是维生素 D 的一种天然存在形式，代谢激活后可以诱导细胞分化和癌细胞增殖。
T41072	Vitamin D3 octanoate Vitamin D3 octanoate
	Vitamin D3 octanoate, an ester derived from vitamin D3, is commonly known as cholecalciferol. Cholecalciferol is a naturally occurring form of vitamin D with notable properties such as inducing cell differentiation and impeding cancer cell proliferation.
T38036	Lumisterol
	Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities[1]. [1]. Anyamanee Chaiprasongsuk, et al. Protective Effects of Novel Derivatives of Vitamin D 3 and Lumisterol Against UVB-induced Damage in Human Keratinocytes Involve Activation of Nrf2 and p53 Defense Mechanisms. Redox Biol. 2019 Jun;24:101206.